The effect of microecological agents on the change of intestinal barrier function after surgery of colorectal cancer
10.3760/cma.j.issn.1673-4904.2009.31.009
- VernacularTitle:微生态制剂对老年结肠癌术后肠道屏障功能的影响
- Author:
Xuquan CHEN
- Publication Type:Journal Article
- Keywords:
Colonic neoplasms;
Drug therapy;
Microecological agents
- From:
Chinese Journal of Postgraduates of Medicine
2009;32(31):23-25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of microecological agents on the change of intestinal barrier function after surgery of colorectal cancer. Methods Seventy-two patients were randomized into control group (36 cases) and test group (36 cases). Both groups received the same treatments excepted that the microecological agents were used in test group. The infection rate of incisional wound, first time of passage gas by anus, incidence rate and time of postoperative diarrhoea, incidence rate of albuminemia, the time of antibiotics administration, duration of fever, the level of D-lactic acid and urine lactulose/mannitol(L/M) were compared. Results In test group, first time of passage gas by anus [(3.1 ±1.2) d],incidence rate of albuminemia (11.1%, 4/36), time of postoperative diarrhoea [ ( 6.2 ±3.1) d ] and duration of fever [(5.1 ± 1.3) d] were lower than those in control group (P< 0.05). The levels of D-lactic acid and urine IVM in both groups at the first day were increased significantly(P < 0.05 ). The levels of D-lactic acid in both groups at the eighth day were decreased significantly (P <0.05). Conclusions Microecological agents can decrease intestinal permeability and maintain the intestinal barrier function after operation. It may be helpful for the recovery of patients after surgery of colorectal cancer.
