Opportunities and challenges in gene therapy of liver cancer
10.3760/cma.j.issn.1673-9752.2010.01.006
- VernacularTitle:肝癌基因治疗的机遇和挑战
- Author:
Cheng QIAN
;
Junjie SHEN
;
Juanjuan SHAN
- Publication Type:Journal Article
- Keywords:
Liver neoplasms;
Gene therapy
- From:
Chinese Journal of Digestive Surgery
2010;9(1):12-14
- CountryChina
- Language:Chinese
-
Abstract:
Gene therapy has emerged as an efficient modality to treat human diseases.This method is based on the transfer of genetic material to tissues to induce a curative effect.Gene therapy vectors are molecular constructs used to facilitate the penetration of genomic sequences inside the cells.Viral vectots have however several limitations when administered directly to the patient.They may cause significant toxicity by activating innate immunity or by eliciting an adaptive immune response against viral proteins.In addition,targeting the vector to the desired site is an issue when given systemically.The use of cells as vehicles for gene therapy vectors has many advantages.The combination of cell-viro-gene therapy has been thought as a new and promising strategy for therapy of cancer.The targeting vector to cancer stem cells will become a new direction in the field of gene therapy.In this article,we will introduce progressions,limitations and future directions of gene therapy of liver cancer.
