Risk factors of complications induced by intraperitoneal chemotherapy after radical resection for colorectal cancer
10.3760/cma.j.issn.1673-9752.2010.01.023
- VernacularTitle:结直肠癌根治术后腹腔化疗并发症的危险因素分析
- Author:
Zhonghua HAN
;
Pan CHI
- Publication Type:Journal Article
- Keywords:
Colonic neoplasms;
Rectal neoplasms;
Intraperitoneal chemotherapy;
Complication;
Risk factor
- From:
Chinese Journal of Digestive Surgery
2010;9(1):61-63
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the risk factors of complications induced by intraperitoneal chemotherapy after radical resection for colorectal cancer,and to summarize the prevention and treatment methods.Methods The clinical data of 234 colorectal cancer patients who received intraperitoneal chemotherapy after radical resection at the Union Hospital of Fujian Medical University from January 1997 to March 2007 were retrospectively analyzed.Risk factors influencing the incidence of complications were determined by analyzing 12 relevant factors with one-way analysis of variance(ANOVA)and Logistic multivariate regression analysis.Results The incidence of complications after intraperitoneal chemotherapy for colorectal cancer was 37.2%(87/234),incidence of catheter-associated complications was 20.5%(48/234),incidence of adhesive ileus was 12.4%(29/234),and the incidence of chemical peritonitis was 19.2%(45/234).The results of one-way ANOVA and Logistic multivariate regression analysis showed that abdominal surgery history,surgical modality,postoperative complications,courses and frequencies of chemotherapy and chemotherapeutics were the risk factors influencing the incidence of complications after intraperitoneal chemotherapy.Conclusions One or two courses of intraperitoneal chemotherapy after radical resection for colorectal cancer is safe with few complications.Chemical peritonitis is the main cause for adhesive ileus after intraperitoneal chemotherapy,maintaining intestinal tract unobstracted during intraperitoneal chemotherapy is effective in preventing adhesive ileus.
