Evaluation of neuron-specific enolase and C-reactive protein on the severity and prognosis of acute cerebral infarction
10.3760/cma.j.issn.1673-4904.2009.31.006
- VernacularTitle:神经元特异性烯醇化酶和C反应蛋白对急性脑梗死病情及预后的评价
- Author:
Xuejie XU
;
Wenyan CHEN
- Publication Type:Journal Article
- Keywords:
Brain infarction;
Phosphopyruvate hydratase;
C-reactive protein;
Prognosis
- From:
Chinese Journal of Postgraduates of Medicine
2009;32(31):15-17
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the levels of serum neuron-specific enolase (NSE) and C-reactive protein ( CRP ) in patients with acute cerebral infarction, and its value on prognosis. Methods The levels of serum NSE and CRP were compared in 92 acute cerebral infarction patients (observation group) and 45 healthy (control group). The relationship between the levels of NSE, CRP and the degree of neurological damage and infarction location were analyzed. Results The levels of serum NSE and CRP were significantly higher in observation group than those in control group (P< 0.01). In observation group, the levels of serum NSE and CRP were higher in heavy patients [ (35.63 ± 7.12) μg/L, (13.82 ± 3.57) mg/L] than those in mild or medium patients [(17.24 ± 5.32) μg/L, (5.61 ± 2.35) mg/L and (26.08 ±5.91) μg/L, (9.07 ±2.14) mg/L,respectively](P<0.01). There was no significant difference in the levels of serum NSE and CRP in different infarction location(P > 0.05 ). Conclusion The level of serum NSE and CRP is an index in reflecting the degree of neurological damage, and they can be used in evaluating patient's condition and prognosis.
