Clinical study on the plasma melatonin level in hypoxie-ischemic encephalopathy neonates
10.3760/cma.j.issn.1673-4912.2010.01.009
- VernacularTitle:新生儿缺氧缺血性脑病血浆褪黑素水平变化的临床研究
- Author:
Meifang LIN
;
Jiarong TAN
;
Jing CHEN
;
Chunjian GU
;
Qinqin FU
;
Qi JIANG
- Publication Type:Journal Article
- Keywords:
Melatonin;
Hypoxic-ischemic encephalopathy;
Infant,newborn
- From:
Chinese Pediatric Emergency Medicine
2010;17(1):23-25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the changes of plasma melatonin(MT)level in hypoxic-ischemic encephalopathy(HIE)neonates,and elucidate the function of rnelatonin in the pathogenesis and the prognosis of HIE.Methods Fourty HIE neonates were divided into 2 groups,20 mild HIE neonates and 20 moderate or severe HIE ones.The femoral vein blood were collected in 48 h and on 7 d after birth in mild HIE group,and in 48 h,on 7 d and(14±4)d after birth in moderate on severe HIE group.Twenty normal term infants served as control group.The level of plasma MT was determined with enzyme-labeled immunosorbent assay.Results Compared with control group[(8.003±1.840)ng/L],The MT level in mild HIE group in 48 h after birth[(13.311±4.025)ng/L]was higher(P＜0.01),but there was no difference on 7 d[(6.605±1.269)ng/L](P＞0.05);The MT level in moderate or severe HIE group in 48 h after birth[(5.487±1.997)ng/L]was lower(P＜0.01),but it was higher on 7 d[(16.201±5.594)ng/L](P＜0.01),there was no difference on(14±4)d[(6.799±1.765)ng/L](P＞0.05).Conclusion MT may have protective action on HIE.The prognosis of HIE with rising MT level in 48 h after birth is better than that with lower MT level.
