CD44s expression study in colorectal cancer tissues
10.3760/cma.j.issn.1007-631X.2009.10.016
- VernacularTitle:CD44s表达与结直肠癌病理分期及预后的关系
- Author:
Hongyi WANG
;
Jin GU
;
Jiantao CUI
;
Youyong Lü
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Neoplasm staging;
Prognosis
- From:
Chinese Journal of General Surgery
2009;24(10):831-833
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between standard CD44(CD44s)expression and tumor stage and prognosis in colorectal cancer.Methods CD44s expression was detected by immunohistochemistry in tumor tissues and normal mucosa specimens from 74 cases of primary colorectal cancer.Results Of 74 cases,the expression of CD44s in colorectal cancer tissue and normal mucosa specimens was documented in 42% and 16%,respectively.The expression of CD44s in primary tumors significantly increased in stage Ⅲ and Ⅳ than in stage Ⅰ and Ⅱ(39% vs.6%,x~2=8.46,P＜0.01).A statistically significant correlation was observed between the overall survival and CD44s expression(x~2=17.82,P＜0.01).Furthermore,a poor prognosis of CD44s-positive tumors was observed in patients with stage Ⅲ and Ⅳ colorectal cancer(x~2=16.23,P＜0.01),but not in patients with stage Ⅰ and Ⅱ colorectal cancer(x~2=1.34,P＞0.05).Multivariate analysis indicated that TNM stage and CD44s expression were independent predictors of overall survival in colorectal cancer.Conclusion CD44s overexpression is involved in the progress of colorectal cancer and predicting the prognosis.
