Study on bone marrow mesenchymal stem cells in repairing of radiation induced acute liver injury of rats
10.3760/cma.j.issn.0254-5098.2010.01.006
- VernacularTitle:骨髓间充质干细胞对大鼠急性放射性肝损伤修复的研究
- Author:
Yongxing BAO
;
Fan LOU
;
Huarong ZHAO
;
Huhu ZHU
;
Yan MA
;
Hao WEN
- Publication Type:Journal Article
- Keywords:
Bone marrow mesenchymal stem cells;
Rats;
Radiation induced liver injury
- From:
Chinese Journal of Radiological Medicine and Protection
2010;30(1):22-25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of mesenchymal stem cells in the repair of radiation induced liver injury.Methods 12 female SD rats were irradiated with 20 Gy 6 MV X-rays on the right lobe of the liver,to establish the model of radiation induced liver injury.The rats were divided randomly into two groups as invention group and control group,and transplanted with 1 ml male mesenchymal suspension or 1 ml normal saline in 4 hours after radiotherapy.The morphological changes of liver were observed.The existence of sex determining gene Y(SRY)and the level of alpha-smooth muscle actin (a-SMA) were detected.Results Some injury of right lobe liver in two groups were observed,and the injury degree of right lobe liver in intervention group were lower than that of control group.The amount of SRY positive cells in the right lobe liver of intervention group was higher than that in the left lobe liver(t = 3.77,P <0.05).The positive expression rate of a-SMA in right lobe liver of intervention group was lower than that of control group.Conclusions Acute radiation induced liver injury could lead BMSCs' homing in order to decrease the degree of liver fibrosis.