Association study between depression and tryptophan hydroxylase 2 gene(rsl386494,G1463A)polymorphism in Yunnan Han population
10.3760/cma.j.issn.1674-6554.2010.02.015
- VernacularTitle:色氨酸羟化酶2基因rs1386494和G1463A多态性与云南汉族抑郁症患者的关联研究
- Author:
Jing CAO
;
Zhuangfei CHEN
;
Xiujie ZHANG
;
Fang LIU
;
Yong ZENG
- Publication Type:Journal Article
- Keywords:
Depression;
Tryptophan hydroxylase 2 gene;
Polymorphism
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2010;19(2):140-142
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association of the two single nucleotide polymorphisms(SNPs) rs1386494 and G1463A of tryptophan hydroxylase 2 gene with depression in Yunnan Han population. Methods A case-control study Was designed by collecting 102 patients and 102 controls.Polymerase chain reaction-restriction fragment length polymorphisms(PCR-RFLP)technique Was used to detect the rs1386494 and G1463A polymorphisms.All patients were evaluated with Hamilton Rating Scale for Depression(HAMD),and scores were compared according to different genotype.Results 1.There were differences in genotype and allele frequency of rsl386494 in Yunnan Han population(X~2=4.300,P=0.038;X~2=4.067,P=0.044).The A allele frequency of rsl386494 in controls Was higher than in patients(P=0.044).2.No genotype of G1463A polymorphism was observed in all samples.3.No significant association genotype of rsl386494 with scores of HAMD Was observed(F=2.461,P=0.120).Conclusion The polymorphism of rsl386494 may be associated with the vulnerability of Yunnan Han population,and the A allele maybe the protective gene for depression.
