Three - dimensional conformal radiotherapy (3DCRT) for 209 patients with esophageal carcinoma
10.3760/cma.j.issn.1004-4221.2010.02.004
- VernacularTitle:209例食管癌三维适形放疗疗效分析
- Author:
Yuxiang WANG
;
Shuchai ZHU
;
Juan LI
;
Jiagwei SU
;
Wenbin SHEN
- Publication Type:Journal Article
- Keywords:
Esophageal neoplasms/Radiotherapy;
Radiotherapy,three - dimensional eonformal;
Prognosis
- From:
Chinese Journal of Radiation Oncology
2010;19(2):101-104
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the outcomes and prognostic factors of esophageal carcinoma treated with three-dimensional eonformal radiotherapy (3DCRT). Methods From January 2001 to August 2007, 209 patients with esophageal carcinoma treated with 3DCRT were retrospectively analyzed. The local control rotes, the survival rates and the related prognostic factors were evaluated with SPSS 11.5 software. Results The follow-up rate was 98. 1% by December 2008. The number of patients followed up for 1,3, 4 and 5 years was 209,131,95 and 56, respectively. The 1-, 3- and 4-year local control rates were 74. 9%, 50. 4% and 45. 8%, respectively. The 1-, 3-and 4-year overall survival rates were 64. 6%, 30. 8% and 23.6%, respectively, with a median survival time of 18 months. Univariate analysis showed that the significant prognostic factors included the degree of dysphagia, tumor site, lesion length in barium esophagogram and CT image, the largest diameter of lesion in CT image, T stage, N stage, clinical TNM stage, short term effect, and degree of acute esophagitis. Multivariate analysis revealed that the degree of dysphagia, primary tumor site, clinical stage, and radiotherapy technique (3DCRT or late half course 3DCRT) were independent prognostic factors. Conclusions Three-dimensional conformai radiotherapy is effective and feasible in the treatment of esophageal cancer. The degree of dysphagia, primary tumor site, and clinical stage are independent prognostic factors for survival of patients treated with 3DCRT.
