Expressions of IL-10, IL-23 and CD86 in lesions of epidermodysplasia verruciformis
10.3760/cma.j.issn.0412-4030.2010.03.020
- VernacularTitle:疣状表皮发育不良患者皮损中IL-10、IL-23和CD86的表达
- Author:
Si LIANG
;
Yuehua LIU
;
Yagang ZUO
;
Kai FANG
;
Baoxi WANG
- Publication Type:Journal Article
- Keywords:
Epidermodysplasia verruciformis;
Interleukin-10;
Interleukin-23;
Antigens,CD86
- From:
Chinese Journal of Dermatology
2010;43(3):196-198
- CountryChina
- Language:Chinese
-
Abstract:
Objective To measure the expressions of IL-10, IL-23 and CD86 in lesions of epidermodysplasia verruciformis (EV), and to explore the relationship between cellular immune abnormality and EV pathogenesis. Methods Immunohistochemistry was used to measure the expressions of IL-10, IL-23 and CD86 in tissue samples from 10 patients with EV and 10 normal human controls. Results Three cytokines were observed in all the samples of EV, with the expression score ranging from 3 to 6 and expression intensity from moderate to high. However, of the control specimens, only 1 was positive for IL-10 with the expression score being 3, and expression intensity being moderate. Conclusion The pathogenesis of epidermodysplasia verruciformis may be correlated with the expression abnormality of some cytokines secreted by keratinocytes.
