Expressions of LAT and VEGF in normal liver tissue, cirrhosis, hepatocellular carcinoma and the relationship between them

VernacularTitle:T细胞活化连接蛋白和血管内皮生长因子在正常肝组织、肝硬化及肝癌中的表达及关系的探讨
Author: Kaifu KANG ; Xin ZHANG ; Xiaowu CHEN ; Aiwen CHE
Publication Type:Journal Article
Keywords: Connexins/ME; Vascular endothelial growth factors/ME; Ldver/ME; Liver cirrhosis/ ME; Liver neoplasms/ME
From: Journal of Chinese Physician 2010;12(1):14-17
CountryChina
Language:Chinese
Abstract: Objective To explore the expressions of LAT and VEGF, and the relationship between them in hepatocellular carcinoma (HCC). Methods The expressions of LAT protein and VEGF protein in SO HCC, 30cirrhosis and 10 normal tissues were assessed by immunohistochemical method. Results The expressions of LAT and VEGF in cancer tissues, cirrhosis tissues, normal tissues were significantly different. The expression of LAT in HCC tissues was stronger than that in cirrhosis, but the expression of VEGF in cirrhosis was stronger than that in HCC tissues. Conclusion The expression of LAT was not closely associated with the expression of VEGF in HCC. The abnormal expressions of LAT and VEGF were closely associated with the development of HCC. They may play important roles in development of HCC.