The protective effects of paeonol against hypoxic-ischemic brain damage of neonatal rats

VernacularTitle:丹皮酚对新生鼠缺氧缺血性脑损伤的保护作用
Author: Ruijun WANG ; Mingyan HEI ; Zhiyu TANG
Publication Type:Journal Article
Keywords: Paeonol/PD; Hypoxia-ischemia,brain/DT
From: Journal of Chinese Physician 2010;12(1):24-26
CountryChina
Language:Chinese
Abstract: Objective To study the protective effect of paeonol against hypoxic-ischemic brain damage of neonatal rats. Methods 36 neonatal SD rats were randomly divided into normal control group, sham group, HIBD group, and HIBD plus Pae group. The expression of cleaved caspase -3 in the damaged cortex of rats was examined by the immunohistochemical staining and the number of necrotic neurons was counted after hematoxylin-eosin staining. Results The number of the cleaved caspase - 3 positive cells in the damaged cortex of rats in the HIBD plus Pae group was significantly lower than that in the HIBD group( P < 0.05 ). The percentage of necrotic neurons was decreased in the HIBD plus Pae group in comparison with HIBD group( P <0.01). Conclusions Paeonol may take protective effect against hypoxic-ischemic brain damage.