Study of the correlation of ET and CGRP in cough variant asthma patients
10.3760/cma.j.issn.1008-6315.2010.03.004
- VernacularTitle:内皮素和降钙素基因相关肽在咳嗽变异型哮喘患者中的相关性分析
- Author:
Songjuan LIN
;
Hairong CHEN
;
Meijuan LIU
;
Jingxia CHEN
;
Ruifang YU
- Publication Type:Journal Article
- Keywords:
Cough variant asthma;
Bronchial asthma;
Endotbelin;
Calcitonin gene-related peptide
- From:
Clinical Medicine of China
2010;26(3):234-236
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the levels of plasma endothelin (ET) and calcitonin gene-related peptide (CGRP) in cough variant asthma(CVA) patients, and to investigate their correlation and clinical implications. Methods Thirty CVA patients,30 typical bronchial asthma patients and 25 healthy controls were recruited. Three milliliter limosis venous blood were drawn from each patient to measure the levels of plasma ET and CGRP by radioimmanity. Results ①The levels of ET in the CVA group and typical bronchial asthma group were higher than that in healthy controls (P < 0.01). Their values were (103.58±28.66) ng/L, (129.37±27.28) ng/L and (72.63±21.52)ng/L, respectively. The levels of CGRP in the CVA group and typical bronchial asthma group were (7.62±2.56) ng/L and(6.63±2.09)ng/L The level of CGRP in the healthy controls group was (21.60±3.29) ng/L. The first two groups were lower than the latter(P < 0.01). However, there was no significant difference between the CVA group and typical bronchial asthma group(P >0.05). ②ET and CGRP were negatively correlated in both CVA group(r= -0.819,P<0.05) and typical bronchial asthma group(r= -0.738,P<0.05). Conclusions ET and CGRP were negatively correlated in both CVA group and typical bronchial asthma group, which means that ET and CGRP were a couple of antagonistic factors participated in the regulation of CVA, and may play an important role in the process of CVA.
