Progress in the pathogenesis of Henoch-Schonlein purpura
10.3760/cma.j.issn.1673-4408.2010.01.013
- VernacularTitle:过敏性紫癜发病机制研究进展
- Author:
Jie CAI
;
Bo HU
- Publication Type:Journal Article
- Keywords:
Henoch-Schonlein purpura;
Nephritis;
Immune injury;
Genes
- From:
International Journal of Pediatrics
2010;37(1):39-41
- CountryChina
- Language:Chinese
-
Abstract:
Henoch-Schonlein purpura(HSP) is one of the most common blood capillary allergic disorder in children, and its pathogenesis has not been well explained. The studies show that the main mechanism of HSP is the abnormality of humoral immunity, and the role of IgA is emphaszed. Meanwhile, many agents such as changes in T cell function,participation of cytokine and mediators of intlammation, suscepti-bility gene and other factors also play an important role in the incidence of HSP. The pathogenesis of HSP can be better understood through extensive analysis of the immunology factors,genetic factors,and so on.
