Role of Toll-like receptors in pathogenesis of rheumatoid arthritis
10.3760/cma.j.issn.1673-4408.2010.01.014
- VernacularTitle:Toll样受体在类风湿性关节炎中的作用
- Author:
Qingkang SHI
;
Lanju CHEN
- Publication Type:Journal Article
- Keywords:
Toll-like receptors;
Rheumatoid arthritis;
Signal transduction
- From:
International Journal of Pediatrics
2010;37(1):42-44
- CountryChina
- Language:Chinese
-
Abstract:
Toll-like receptors(TLRs), as the family members of type Ⅰ transmembrane receptors, play a pivotal role in both innate and adaptive immune responses. Recently, TLRs are believed to be the cntical receptors in innate immunity . Innate immunity activated by the recognition of exogenous or endogenous by TLRs induces multiple cytokines that is the key factor to affect differentiation of naive T cells. Abnormal activation of TLIRs may cause the functional imbalance of Th1, Th2, Th17 and Treg, resulting in the occurence of autoimmune disease.
