Advances in chronic active Epstein-Barr virus infection
10.3760/cma.j.issn.1673-4408.2010.01.025
- VernacularTitle:慢性活动性EB病毒感染的研究进展
- Author:
Chenguang XU
;
Xiaoyu LI
- Publication Type:Journal Article
- Keywords:
Epstein-Barr virus;
Infection
- From:
International Journal of Pediatrics
2010;37(1):78-81
- CountryChina
- Language:Chinese
-
Abstract:
Chronic active Epstein-Barr virus infection( CAEBV) is an undefined illness, which is often characterized by severe. chronic, or recurrent infectious mononucleosis-like syndrome, such as fever, hepatosplenomegaly, persistenthepatitis and extensive lymphadenopathy . Patients with CAEBV have high viral loads in their penpheral blood and/ or an unusual pattem of EBV-related antibodies. It is an intractable disease with a poor prognosis. Patients with CAEBV have high mortality from hepatic failure, opportunistic infection, or hemophagocytic lymphohistiocytosis. A definite treatment has not been established . There is accumulating evidence that the clonal expansion of EBV-infected T or natural killer cells play a key role in the pathogenesis of CAEBV.
