Effects of celecoxib a COX-2 inhibitor on postoperative abdominal adhesion in rats
10.3760/cma.j.issn.1007-631X.2010.03.019
- VernacularTitle:环氧化酶2抑制剂对大鼠术后腹腔粘连的影响
- Author:
Guangbing WEI
;
Xuqi LI
;
Kang WANG
;
Hongliang DUAN
;
Mingming JI
;
Peibin YANG
- Publication Type:Journal Article
- Keywords:
Postoperative complications;
Cyclooxygenase 2;
Disens models,animal;
Cyclooxygenase 2 inhibitors;
Tissue adhesions
- From:
Chinese Journal of General Surgery
2010;25(3):235-238
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the corelation between the expression of COX-2 and postoperative adhesions and to determine the effect of COX-2 selective inhibitor,Celecoxib,on postoperative adhesion formation. Methods Fifty SD rats were randomly assigned to five groups each consisting of 10 rats,Study groups were as follows:(A)positive control group,(B)sodiumhyahronate group,(C)low dose Celecoxib group,(D)high dose Celecexib group,(E)negative control group,Five rats in each group were treated accordingly for consecutive 8 days and 15 days respectively and sacrificed,After treatment,intra-abdminal adhesions were scored using a standard method.The adhesions tissure and injured peritonaeum were subjected to Westem-blotting to detect the expression of COX-2. Results The level of postoperative adhesions and expression of COX-2 of sodiumhyahronate group、low dose Celecoxib group、high dose Celecoxib group were lower than that of positive control group(P<0.05),Sediumhyahronate treatment group was different formthe two Celecoxib treated groups(P<0.05).Conclusions Selective COX-2COX-2.mechanism,provides durable inhibition of intra-abdominal adhesions through an antiangiongenic COX-2 mechanism.
