Levels of serum interleukin-6 and interlenkin-18 in newly diagnosed type 2 diabetes mellitus

VernacularTitle:新诊断2型糖尿病患者血清白细胞介素6和白细胞介素18水平的研究
Author: Qi ZHUANG ; Jianhua MA
Publication Type:Journal Article
Keywords: Diabetesmellitus,type2; Interleukin-6; Interleukin-18; Insulin resistance
From: Chinese Journal of Postgraduates of Medicine 2010;33(7):7-10
CountryChina
Language:Chinese
Abstract: Objective To explore the levels of serum interleukin-6 and interleukin-18 in newly diagnosed type 2 diabetes mellitus (T2DM) and investigate their roles. Methods The serum interleukin-6 and interleukin-18 levels were detected in 50 newly, diagnosed T2DM patients (T2DM group) and 40 normal subjects (control group). Fasting blood glucose, fasting insulin, blood lipid, body mass index (BMI) and waist/hip ratio (WHR) were measured. HOMA-IR and HOMA-β were calculated. Results The serum interleukin-6 and interleukin-18 levels in T2DM group were significantly higher than those in control group [(2.56 ± 1.09) ng/L vs (1.81±0.80) ng/L, (5.38±0.91) ng/L vs (4.62±0.59)ng/L] (P <0.01).Interleukin-6 level was positively correlated with HbA_1c,while interleukin-18 level was positively correlated with BMI and WHR. Interleukin-6 and interleukin-18 levels were positively correlated. Interleukin-6 and interhukin-18 could predicted the insulin resistance. Conclusion Interleukin-6 and interleukin-18 take part in the development of T2DM, and can be related to the insulin resistance.