The role of Syk in migration and proliferation of the vascular smooth muscle cells
10.3760/cma.j.issn.1673-4408.2010.02.015
- VernacularTitle:Syk与血管平滑肌细胞的增殖和迁移
- Author:
Zhengxiang GAO
;
Hanmin LIU
- Publication Type:Journal Article
- Keywords:
Spleen tyrosine kinase;
Vascular smooth muscle cells;
Signal transduction
- From:
International Journal of Pediatrics
2010;37(2):155-157
- CountryChina
- Language:Chinese
-
Abstract:
Spleen tyrosine kinase(Syk) has been considered to be a signaling molecule of hematopoietic cells,which play an important role in lymphocyte maturation and activation of immune cells.Recent studies showed that Syk plays a crucial role in regulation of proliferation and migration in vascular smooth muscle cells.Prominent pathways include mitogen-activated protein kinases,phosphatidylinositol 3-kinases,Src and Rho-activated protein kinase.In this review,the role of Syk in those signal pathways is summarized.
