Collision of Three Histologically Distinct Endometrial Cancers of the Uterus.
10.3346/jkms.2012.27.1.89
- Author:
Ki Seok JANG
1
;
Won Moo LEE
;
Young Jae KIM
;
Sam Hyun CHO
Author Information
1. Department of Pathology, College of Medicine, Hanyang University, Seoul, Korea.
- Publication Type:Case Reports ; Review
- Keywords:
Uterus;
Collision Tumor;
Endometrial Neoplasms
- MeSH:
Aged;
Aromatase Inhibitors/therapeutic use;
Carcinoma, Endometrioid/drug therapy/*pathology/surgery;
Chemotherapy, Adjuvant;
Cystadenocarcinoma, Papillary/drug therapy/*pathology/surgery;
Endometrial Neoplasms/drug therapy/*pathology/surgery;
Female;
Humans;
Hysterectomy;
Immunohistochemistry;
Keratins/metabolism;
Lymphatic Metastasis;
Mixed Tumor, Mullerian/drug therapy/*pathology/surgery;
Nitriles/therapeutic use;
Triazoles/therapeutic use;
Tumor Suppressor Protein p53/metabolism
- From:Journal of Korean Medical Science
2012;27(1):89-92
- CountryRepublic of Korea
- Language:English
-
Abstract:
A collision tumor is defined by the presence of two separate masses in one organ, which are pathologically distinct. We described a 70-yr-old patient who complained of abnormal vaginal bleeding with a collision tumor of the uterine corpus. The patient received total hysterectomy, bilateral salphingo-oophorectomy, bilateral pelvic-paraaortic lymphadenectomy, omentectomy, and intraperitoneal chemotherapy. The uterine corpus revealed three separate masses, which were located at the fundus, anterior and posterior wall. Each tumor revealed three pathologically different components, which were malignant mixed mullerian tumor, papillary serous carcinoma, and endometrioid adenocarcinoma. Among these components, only the papillary serous carcinoma component invaded the underlying myometrium and metastasized to the regional lymph node. Adjuvant chemotherapy and radiation therapy were performed. The patient is still alive and has been healthy for the last 8 yr. We have reviewed previously reported cases of collision tumors which have occurred in the uterine corpus.
