Progress in the pathogenesis and management of mesangial proliferative glomerolonephritis
10.3760/cma.j.issn.1673-4408.2010.02.023
- VernacularTitle:系膜增生性肾小球肾炎发病机制及治疗进展
- Author:
Fangzheng TANG
;
Yalan LIU
;
Feiqiu WEN
- Publication Type:Journal Article
- Keywords:
Mesangial proliferative glomerulonephritis;
Pathogenesy;
Management
- From:
International Journal of Pediatrics
2010;37(2):179-182
- CountryChina
- Language:Chinese
-
Abstract:
Mesangial proliferation is a basic pathologic process of many kidney diseases,mesangial proliferative glomerulonephritis(MsPGN) is the common pathological type.The pathogenesis of MsPGN still remains unclear.Recently,cytokines of fractalkine,interleukin and TGF-β gradually become hotspot in the pathogenesis of MsPGN.Studies shows that a variety of cytokines play an important roles in the development of MsPGN and the mechanism has been gradually clarified.Certain progress has been made in treatment,and more profound understanding of mycophenolate mofetil has been received,the treatment of the MsPGN as manifestations with refractory nephrotic syndrome has been achieved good effect.This review is based on the recent years of the primary non-IgA MsPGN progress.
