Analysis for the clinical pathological characters of extranodal Nasal-type natural killer cell/T cell lymphoma
10.3760/cma.j.issn.1008-1372.2010.02.017
- VernacularTitle:结外鼻型NK/T细胞淋巴瘤的临床及病理学特征分析
- Author:
Xincheng ZHOU
;
Yin MIAO
;
Xiuming QI
- Publication Type:Journal Article
- Keywords:
Nose neoplasms/PA;
Lymphoma,T-cell/PA
- From:
Journal of Chinese Physician
2010;12(2):194-196
- CountryChina
- Language:Chinese
-
Abstract:
Objective To summarize the clinical histopatholngical characteristics of extranodal na-sal-type natural killer cell / T cell lymphoma. Methods 21 cases of nasal-type extranodal natural killer cell / T cell lymphoma were studied by retrospective analysis on its connection with their clinical manifesta-tions and histopathological features. Immunohietochemical SP method was used to detect the expression of immunophenotype, virus( EBV), and etc, in 21 cases. Results Capillaries had varied degrees hyperplasi-a in all cases under the microscope. Tumor cells showed definite devastating infiltration around the blood vessels, its infiltrating representation was found below intima and among vessel wall, and multiple mixed in-flammatory cells were found in it as well. Squamous epithelial pseudotumor-like proliferating can be seen in 1 case. All tumor cells'immnnophenotype were T-cell differentiation antigen CD45RO( + ), T-cell related antigen CD56 (+), T-cell particle-associated antigen TIA-1 (+), EBV (+). Conclusion Nasal-type extranodal natural killer cell / T cell lymphoma has characteristic clinical expression and histopathological changes. Accurate diagnosis can be obtained on the basis of its typical clinical expression, pathomorphology changes, immunophenotype and EBV( + ) in situ hybridization.
