De Novo urinary and male genital cancers in kidney transplant recipients

VernacularTitle:肾移植受者新发泌尿及男性生殖系统恶性肿瘤的生存分析
Author: Yun MIAO ; Lixin YU ; Wenfeng DENG ; Yuejun DU ; Shaojie FU ; Jian XU ; Chuanfu DU ; Yibin WANG ; Qiang WEI ; Guirong YE
Publication Type:Journal Article
Keywords: Kidney transplantation; Genitourinary system; Carcinoma; Immunosuppres-sive agents
From: Chinese Journal of Urology 2010;31(3):175-178
CountryChina
Language:Chinese
Abstract: Objective To explore the outcomes of kidney transplant recipients who developed urinary and male genital cancers after transplantation. Methods Data of 31 kidney transplant recipients developed de novo urinary and male genital cancer were compared with data of 31 patients in general population with the same age and same tumor stage. Results Compared with the general population, the overall survival was significantly worse in the transplant recipients (P=0. 02) , 5-year survival rates for each group were 50% vs 68%. Multivariate analyses demonstrated cancer stage to be a negative risk factor for survival for transplant recipients with de novo urinary and male genital cancer, and surgery and functioning graft to be the positive survival predictors. Conclusions Transplant recipients experience worse outcomes than the general population from urinary and male genital cancers. Cancers in transplant recipients are more biologically aggressive at the time of diagnosis.