Neuroimmunological mechanisms of infection after acute stroke
10.3760/cma.j.issn.1673-4165.2010.02.009
- VernacularTitle:急性卒中后感染的神经免疫机制
- Author:
Junjie HAO
;
Tianheng ZHENG
;
Shaoshi WANG
- Publication Type:Journal Article
- Keywords:
Stroke;
Infection;
Immunologic deficiency syndromes;
Sympathetic nervous system
- From:
International Journal of Cerebrovascular Diseases
2010;18(2):124-127
- CountryChina
- Language:Chinese
-
Abstract:
Infection is one of the most important complications of acute stroke, and it is an independent risk factor for resulting in stroke worsening. Growing evidence has indicated that acute stroke patients suffer an impaired peripheral immune response, i.e. stroke-induced immunodepression system (SIDS). SIDS is characterized by the rapid and sustained cellular immunodepression after acute stroke, which is mainly presented as wide apoptosis and dysfunction of lymphocyte. Multiple reasons activate the sympathetic nervous system, and thus cause SIDS. SIDS weakens the effective defense against the invasion of pathogens in the human body, resulting in the increased infection and mortality rate. However, SIDS also has protective effect on the human body. It can prevent the excessive inflammatory response in the injured brain tissue. A better understanding of the complex relationships between the central nervous system and the immune system are promising to provide more effective treatment methods for patients with acute stroke.
