Diagnostic analysis of different index in adult onset Still's disease
10.3760/cma.j.issn.1007-7480.2010.03.014
- VernacularTitle:不同指标在成人斯蒂尔病中诊断结果分析
- Author:
Zhen WANG
;
Lindi JIANG
;
Jie GU
- Publication Type:Journal Article
- Keywords:
Diagnosis;
Still's disease,adult-onset;
Sensitivity;
Specificity
- From:
Chinese Journal of Rheumatology
2010;14(3):192-194
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the value of clinical findings and different diagnostic criteria for the diagnosis of adult onset Still's disease (AOSD). Methods The AOSD patients admitted to Zhongshan Hospital affiliated to Fudan University from 2003 to 2009 were enrolled. Non-AOSD patients with fever were selected. Different diagnostic criteria of AOSD were applied to all patients. Two indenpendent samples t test and wilco-xon test were used for statistical analysis. Results The clinical features such as rash, arthralgia, arthroncus, sore throat, myalgia, lymph node enlargement, hepatomegaly, splenomegaly, leuko-cytosis, neutrophil ≥80% and serum level of ferrin≥ 2000 ng/ml hadhigher specificity (65.87%~98.41%) with 2.00～5.00 of the positive likelihood ratio.High fever ( ≥39.0℃), negative of ANA and RF had higher sensi-tivity (85.25%~93.65%). Combinations of three parameters such as high fever, rash, sore throat, leukocy-tosis, arthralgia had higher positive likelihood ratio. The specificity of ARA criteria was the highest. The sensitivity and accuracy of Yamaguchi criteria were the highest. Conclusion There is no single parameter that could be specific to the identification of AOSD. Combing with several parameters can improve the diagnostic efficiency. The results of this study have shown that the commonly used diagnostic criteria has high specificity.
