High mobility group box-1 and tumor
10.3760/cma.j.issn.1673-422X.2010.01.004
- VernacularTitle:高迁移率族蛋白B1与肿瘤的相关性
- Author:
Benhong MA
;
Jing LIANG
;
Zengyan ZU
- Publication Type:Journal Article
- Keywords:
HMGB1 protein;
Neoplasms;
Receptors
- From:
Journal of International Oncology
2010;37(1):12-15
- CountryChina
- Language:Chinese
-
Abstract:
High mobility group box-1 (HMGBI)is a kind of non-histone chromatin-binding protein in nucleus.HMGB1 is intimately associated with the regulation of transcription,inflammation and rheumatic disease through binding the receptor.Recently,HMGB1 is overexpressed in several malignant tumors,and the expression level is positively correlated with the degree of differentiation,tumor invasion and metastasis.HMGB1 may be a new target molecule of antitumor.
