Role of hydrogen sulfide in the cardiovascular diseases
10.3760/cma.j.issn.1673-4203.2010.03.019
- VernacularTitle:硫化氢在心血管疾病中的作用
- Author:
Bingbing MA
;
Fuxian ZHANG
;
Gangzhu LIANG
- Publication Type:Journal Article
- Keywords:
Hydrogen sulfide;
Cardiovascular disease;
Gasotransmitter
- From:
International Journal of Surgery
2010;37(3):196-199
- CountryChina
- Language:Chinese
-
Abstract:
Endogenous hydrogen sulfide (H_2S) is to third found gaseous transmitter.In cardiovascular system, H_2S is produced endogenously by cystathionine γ-lyase (CSE)and plays an important role in the regulation of cardiovascular physiologic function and patho physiological processes.The CSE/H_2S system has a variety of biological effects in the cardiovascular system, such as inducing vasorelaxation,decreases blood pressure,inhibiting vascular smooth muscle cell proliferation and inducing anti-oxidant.It is also concerned with variety of cardiovascular diseases such as hypertension, hyperlipemia, atherosclerosis,coronary artery disease and so on.We summarize the biochemical characteristics and the physiological functions of endogenous H_2S and its patho physiological effects in cardiovascular diseases.
