The expression of Survivin and its implication to clinic pathology and prognosis in breast cancer tissue microarray

VernacularTitle:乳腺癌组织芯片中Survivin的表达及与临床病理特征和预后的关系
Author: Wei WU
Publication Type:Journal Article
Keywords: Breast neoplasms/ME/PA; Mierotubule-associated proteins/ME; Prognosis
From: Journal of Chinese Physician 2010;12(2):197-199
CountryChina
Language:Chinese
Abstract: Objective To investigate the'expression of Survivin in breast cancer tissue microarray, and its implication to clinic pathology and prognosis. Methods The expression of Survivin was studied in 80 cases of breast disease tissues ( 18 cases of hyperplasia of mammary glands and 62 cases of breast canc-er) and 20 cases of adjacent normal tissues by S-P immunohistochemisty to analysis the relationships be-tween its expression and history grade, clinic stage and lymphaden metastasis. Results The positive rates of Survivin were 0(0/20) in normal mammary glands, 33. 3% (6/18) in hyperplasia of mammary glands and 72. 5% (45/62) in breast cancer. There were significant difference between them (X~2= 34. 62, P <0. 01 ). The expression of Survivin was closely correlated to the stage and lymphaden metatasis and survival time ( P <0.05 or P <0.01), and it was negatively correlated to the histological grade ( P >0.05).Conclusions The expression of Survivin shows an ascending tendency in the carcinogenesis and progres-sion of breast cancer. The Survivin can promote the invasion and the metastasis of the cancer cell, and it is closely correlated to the prognosis.