Brain activation differences in first-episode and recurrent depressed patients during the recognition of sad facial expression
10.3760/cma.j.issn.1674-6554.2010.02.008
- VernacularTitle:首发与复发抑郁症患者识别悲伤面部表情的脑功能差异研究
- Author:
Qing LU
;
Jing ZHANG
;
Zhijian YAO
;
Yinglin HAN
;
Li WANG
;
Haiyan LIU
- Publication Type:Journal Article
- Keywords:
Depression;
First episode;
Recurrent;
Emotion;
Recognition
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2010;19(2):118-120
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the difference in the intensity of brain activation during the recognition of sad facial expression and changes in neuropsychology cognition in patients with a first depressive episode and with recurrent depression.Methods 11 patients with a first major depressive episode,11 patients with recurrent major depression and 11 healthy controls matched in all aspects were scanned to compare the intensity of brain activation in the process of sad and neural facial expression recognition Results Compared with the healthy,first-episode depressed patients showed increased activation in right cuneus(BA18),right fusiform gyrus(BA20),left medial frontal gyrus(BA6),left middle temporal gyrus(BA39),left parahippocampal gyrus(BA30)and decreased activation in right temporal gyrus(BA22),right parahippocampal gyrus(BA27);recurrent depressed patients showed increased activation in right medial frontal gyrus(BA6),right superior temporal gyrus(BA38)but no activation increased.In comparation with the first-episode depressed,the recurrent,showed decreased activation in right middle frontal gyrus(BA6),fight thalamus,right superior temporal gyrus(BA22),right precentral gyras(BA44),right claustrum and increased activation in right parahippocampal gyrus(BA28),right claustrum,right insula(BA13). Conclusion The neural correlates of patients with depression,especially the first-episode depressed for recognition of sad facial expression is different from the healthy with more brain regions involved in the process.There are also differences in the neural basis for recognition of sad facial expression between patients with a first depressive episode and patients with recurrent depression.Performances of brain regions related with emotional recognition de-clined more in the recurrent depressed.
