Hypoxia-inducible factor-1α and small ubiquitin-related modifier
10.3760/cma.j.issn.1673-4408.2010.02.003
- VernacularTitle:缺氧诱导因子-1与小泛素相关修饰物
- Author:
Li ZHANG
;
Yi QU
;
Dezhi MU
- Publication Type:Journal Article
- Keywords:
Hypoxia-inducible factor-1;
Small ubiquitin-related modifier;
Posttranslational modification
- From:
International Journal of Pediatrics
2010;37(2):116-118
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia-inducible factor-1 (HIF-1) is a key transciptional regulator of cellular and systemic oxygen homeostasis,composed of the two subunits,HIF-1α and HIF-1β.HIF-1α is an inducible subunit regulated by hypoxia,which is posttranslationally modified by various ways,including ubiquitination,phosphorylation,hydroxylation,acetylation and glycation,accordingly affecting its protein's stability,nuclear translocation and regulation of its target genes.Small ubiquitin-related modifier (SUMO) is an micromolecule protein participating in posttranslational modifications of proteins dynamicly in eukaryotic organism,which is similar in structure to ubiquitin.SUMOylation and deSUMOylation are involved in multiple regulations of biologic processes,such as signal transduction,transcriptional regulation,cell cycle processes and biological rhythm.SUMOylation is related to HIF-1α stability and transcription activity in hypoxia,providing a newthread to study self-regulation mechanism of HIF-1α for us.
