Advancement in researches of mechanism of nervous invasion of pancreatic cancer and its countermeasures
10.3760/cma.j.issn.1007-8118.2010.03.027
- VernacularTitle:胰腺癌神经侵犯机制及应对策略的研究进展
- Author:
Peng CHENG
;
Gang JIN
;
Xiangui HU
- Publication Type:Journal Article
- Keywords:
Pancreatic cancer;
Perineural invasion;
Mechanism
- From:
Chinese Journal of Hepatobiliary Surgery
2010;16(3):229-232
- CountryChina
- Language:Chinese
-
Abstract:
Perineural invasion(PNl) is regarded as a factor associated with local recurrence and an important prognostic factor in pancreatic cancer.Little is known about the mechanism of PNI in Pancreatic cancer.This review summarizes the role of innervation, clinicopathologic factors, lymhatic vessels, vascularity, cytokines, adhesion molecules, some immunoglobulin superfamily members and mucin in PNI.Because PNI is often followed by poor survival.An ear-lier diagnosis can improve pancreatic cancer prognosis.IPEUS,CT scan and immunostaining CK-19, K-ras gene a-nalysis can be used to diagnose perineural invasion pre-, in-tra-or postoperatively.A wide surgical exeresis with an enough lymph nodes clearance together with surrounding connective and nervous tissue can get a better long term survival rate.
