Islet β-cell function in subjects with normal glucose tolerance at above 30 years of age
10.3760/cma.j.issn.0254-9026.2010.03.022
- VernacularTitle:中老年正常糖耐量人群胰岛β细胞功能分析
- Publication Type:Journal Article
- Keywords:
Glucose tolerance test;
Insulin-secreting cells
- From:
Chinese Journal of Geriatrics
2010;29(3):250-252
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between fasting plasma glucose (FPG) level and insulin secretion in normal glucose tolerance (NGT) subjects.Methods Totally a community-based population of 2095 residences aged above 30 years received oral glucose tolerance test (OGTT), and was classified according to FPG and 2-hour plasma glucose (2 hPG) into NGT group, impaired glucose tolerance (IGT) group, impaired fasting glucose (IFG) group, both IGT and IFG (IFG/IGT) group and diabetes mellitus (DM) group.The subjects in NGT group were further divided into 6 groups according to age and FPG separately, the HOMA β-cell function index (HBCI) was compared among the groups.Results For the patients in NGT group, the FPG level was higher in group aged 60-69 years than in group aged 50-59 years [(5.17±0.48)mmol/L vs.(5.09±0.44)mmol/L, P<0.05], and was also higher in group aged 50-59 years than in group aged 40-49 years [(5.09±0.44) mmol/L vs.(5.00± 0.47) mmol/L, P<0.01].A decreasing tendency of HOMA-β and fasting insulin level with age could be observed with statistical significance.The HBCI was lower in NGT group with FPG above 5.0 mmol/L than with FPG below 5.0 mmol/L (4.22±0.70 vs.4.39±0.58, P<0.05).HBCI was negatively correlated with age as the main factor.Conclusions In NGT subjects, the FPG increases with age and there may be abnormality of insulin secretion in subjects with FPG higher than 5.0 mmol/L.
