Neoplasms chemoresistance induced by mutated mechanisms of apoptosis
10.3760/cma.j.issn.1673-422X.2010.01.009
- VernacularTitle:凋亡机制异常导致的肿瘤耐药
- Author:
Yao ZHAO
- Publication Type:Journal Article
- Keywords:
Apoptosis;
Drug resistance,neoplasm;
Gene therapy
- From:
Journal of International Oncology
2010;37(1):27-30
- CountryChina
- Language:Chinese
-
Abstract:
Tumor chemoresistance can lead to chemotherapy failure.Research have identified multiple mutations in both the death receptor and mitochondrial apoptotic pathways,which result in tumor resistance to chemotherapy.Further understanding of the molecular mechanisms of abnormal apoptosis will facilitate the development of targeted tumor therapies.Novel drugs targeting the mutated apoptotic pathways are availble or in the clinic trial.
