Vasovagal syncope and serotonergic system
10.3760/cma.j.issn.1673-4408.2010.02.012
- VernacularTitle:血管迷走性晕厥和5-羟色胺能系统
- Author:
Yao LIN
;
Lin SHI
- Publication Type:Journal Article
- Keywords:
Syncope;
Vasovagal syncope;
Serotonin;
Serotonin reuptake inhibitors
- From:
International Journal of Pediatrics
2010;37(2):145-148
- CountryChina
- Language:Chinese
-
Abstract:
The role of serotonergic system in vasovagal syncope (VVS) has been more concerned.Serotonin is a kind of neurotransmitter which is widely distributed in central nervous system.There are kinds of serotonergic receptors on postsynaptic membrane,among which 5-HT1A receptors participate in the mechanism of central blood pressure depression and promote the release of hormones such as prolactin and adrenocorticotrophic hormone.Acute administration of selective serotonin reuptake inhibitors (SSRIs) during head-up tilt test (HUT) blocks the reuptake of serotonin in the synapse space and thus increases stimulation of the serotonin receptors,which induces syncope episode.Long-term administration of SSRIs downregulates the postsynaptic serotonergic receptors,thus it weakens the reaction to the rapid change of serotonin concentration, which results in rapid depression of sympathic nerves and prevention of syncope episode.These demonstrate that central serotonergic system may participate in the pathogenesis of VVS and SSRIs are important for the diagnosis and treatment of VVS.
