Fractalkine and its receptor CX3 CR1 and cerebrovascular diseases
10.3760/cma.j.issn.1673-4165.2010.02.013
- VernacularTitle:Fractalkine及其受体CX3CR1与脑血管病
- Author:
Lie WU
;
Lan WU
- Publication Type:Journal Article
- Keywords:
Cerebrovascular disorders;
Brain ischemia;
Reperfusion injury;
Chemokines,CX3C;
Receptors,cytokine;
Polymorphism,genetic
- From:
International Journal of Cerebrovascular Diseases
2010;18(2):142-145
- CountryChina
- Language:Chinese
-
Abstract:
Fractalkine is a new member of chemokine family, which exists in membrane-boundd form and soluble form. It has both adhesion molecular and chemokine activities. CX3 CR1 is its specific receptor. Both of them were expressed in many diseases of the nervous system. At present, fractalkine and its receptor CX3CR1 polymorphism and the research of cerebrovascular diseases mainly involve in the risk factors for cerebrovascular diseases, cerebral ischemia-reperfusion and bone marrow stem cell transplantion, which are expected to become a new target for clinical treatment.
