Progress on B7H1/PD-1 pathway in tumors
10.3760/cma.j.issn.1673-4203.2010.03.016
- VernacularTitle:B7H1及其受体病理作用的研究进展
- Author:
Qingsong WU
;
Dongsheng HUANG
- Publication Type:Journal Article
- Keywords:
B7H1;
PD-1 receptor;
T cell;
Tumors
- From:
International Journal of Surgery
2010;37(3):187-190
- CountryChina
- Language:Chinese
-
Abstract:
B7H1 is a recently described B7 family member.Ligation of PD-1 receptors with B7hl on the surface of activated T cell inhibits T cell proliferation and cytokine production. B7H1 plays a negative regulatory role in peripheral tolerance, autoimmune diseases and chronic infections.B7H1 also has been found to be largely expressed on a broad range of cancers and is thought to contribute to immune evasion by cancers. Blockade of B7H1/PD-1 pathway may contribute to the treatment of autoimmune diseases and maligant tumors.
