Therapeutics of neonatal respiratory distress syndrome with nasal continuous positive airways pressure combined with pulmonary surfactant

VernacularTitle:经鼻持续气道正压通气联合肺表面活性物质治疗新生儿呼吸窘迫综合征
Author: Chaohai WANG ; Guangyu WEI ; Rongwei MA
Publication Type:Journal Article
Keywords: Nasal continuous positive airway pressure; Mechanical ventilation; Pulmonary surfactant; Neonatal respiratory distress syndrome
From: Clinical Medicine of China 2010;26(3):323-325
CountryChina
Language:Chinese
Abstract: Objective To evaluate the clinical effects of nasal continuous positive airway pressure (NC-PAP) and surfactant administration in preterm infants with neonatal respiratory distress syndrome(NRDS) Methods A prospective randomized study was conducted, in which infants <32 weeks' gestation with NRDS were random-ized to the aurfactant-NCPAP (S-N) group or the surfactant-mechanical ventialtion (S-M) group. Results At 7 days after birth, 1 infant (6.25%) in the S-N group and 8 infants (47.00%) in the S-M group were still undergo-ing mechanical ventilation. The duration of oxygen therapy, NCPAP and mechanical ventilation,the need for a sec-ond dose of surfactant, and the days of staying in the intensive care unit were significantly greater in the S-M group. Conclusions The immediate application of NCPAP after surfactant administration for infants with NRDS is safe and beneficial.