Progress of TRAIL and its application in leukemia therapy
10.3760/cma.j.issn.1673-4408.2010.02.010
- VernacularTitle:TRAIL及其在白血病治疗中的研究进展
- Author:
Lin HAN
;
Xiuhong JIA
- Publication Type:Journal Article
- Keywords:
TNF related apoptosis-inducing ligand;
Leukemia;
Apoptosis
- From:
International Journal of Pediatrics
2010;37(2):139-141
- CountryChina
- Language:Chinese
-
Abstract:
Tumor necrosis factor-related apoptosis-inducing ligand(TRAIL) is a new anti-tumor biological agents which is very hot in recent years through its death receptor-induced apoptosis of tumor cells,and non-toxic to normal cells,and has synergy with the chemotherapy drug,but there is also resistance mechanisms.This article will review the biological characteristics of TRAIL and its receptors,TRAIL-induced apoptosis of tumor cells,as well as the mechanism of TRAIL in leukemia in the progress of treatment.
