Expression and significance of integrin linked kinase in pancreatic carcinoma

VernacularTitle:整合素连接激酶在胰腺癌中的表达及意义
Author: Wei LIU ; Shaowei SONG ; Gang MA ; Rui SHI ; Ying CHENG ; Ning LIU ; Kejian GUO
Publication Type:Journal Article
Keywords: Pancreatic neoplasms; Intergrin linked kinase; Immunohistochemistry; Western blotting
From: Chinese Journal of Pancreatology 2010;10(1):31-33
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression and clinical significance of intergrin linked kinase (ILK) in pancreatic carcinoma.Methods ILK protein was detected by immunohistochemistry and Western blotting in 60 cases of pancreatic carcinoma and 32 cases of normal pancreatic tissue,and the relationship with the clinicopathological characteristics were analyzed.Results Immunohistochemistry showed ILK was expressed in cytoplasm and membrane of pancreatic carcinoma cells and the positive rate was 65% (39/60),which was significantly higher than 18.75% (6/32) of normal pancreatic tissue(P ＜0.05 ).Western blotting showed the expression of ILK in pancreatic carcinoma tissue was 303933±195116,which was significantly higher than 144613±30074 of normal pancreatic tissue(P＜0.05 ).In pancreatic carcinoma,the expression of ILK was correlated with clinical stage and lymph metastasis(P＜0.05 ),but not correlated with tumor cell differentiation(P＞0.05 ).Conclusions ILK protein was highly expressed in pancreatic carcinoma tissue and it was correlated with the degree of malignancy.