Study on analgesic effects of combination of fortanodyn and verapamil
10.3760/cma.j.issn.1008-6706.2010.04.005
- VernacularTitle:布桂嗪合用维拉帕米的镇痛作用研究
- Author:
Bing LI
;
Lei ZHANG
;
Fulin ZHENG
- Publication Type:Journal Article
- Keywords:
Analgesics;
Verapamil;
Pain measurement
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(4):441-442
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the analgesic effects of combination of fortanodyn and verapamil. Methods Used the model of the acetic acid induction writhing in mice and the method of hot-plate in mice, then observe the action of the mice after treatment with combination of fortanodyn and verapamil. Results Low dose Verapamil com-bined AP237 (40 mg/kg, 80 mg/kg)could enhance the threshold of pain of the mouse ache response obviously, and postponed the time which the mouse ache appeared (comparing using simply AP237 P <0.05 with controlled group P <0. 01) ;Low dose Verapamil combined AP237 (20 mg/kg,40 mg/kg) had the obvious inhibitory action in the body turning times of the mouse. Conclusion Verapamil can strengthen the analgesia function of AP237.
