Protective effects of cordyceps sinensis and mycelium of cultured sinensis on acute liver injury and expression of CYP450 induced by Carbon Tetrachloride
10.3760/cma.j.issn.1008-6706.2010.04.013
- VernacularTitle:冬虫夏草及人工虫草丝菌提取物对四氯化碳致急性化学性肝损伤小鼠的保护作用
- Author:
Xixia YANG
;
Xiaohong CHEN
;
Fangjun CHEN
;
Rong HU
;
Zhuang CAO
;
Xiaoyu CHEN
- Publication Type:Journal Article
- Keywords:
Cordyceps Sincnsis;
Mycelium of Cultured Sinensis;
Hepatitis,toxic;
Cytoehrome P450 enzyme system
- From:
Chinese Journal of Primary Medicine and Pharmacy
2010;17(4):457-459
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Cordyceps Sinensis and Mycelium of Cultured Sinensis on acute injury in this test and expression of CYP450. Methods Mice received a single dose of 0. 1% CCl_4 i. p, after CCl_4 intoxication,mice received Cordyceps Sincnsis and Mycelium of Cultured Sinensis (100mg/ml) 3 times per six hour,then the mice sacrificed at 6h,12h,24h,the levels of aminotransferase (ALT) and glutathione (GSH) in ser-um,CYP45 content in hepatic microsomal activity in fiver homogenate were measured. Results Mice given Cordyceps Sinensis and Mycelium of Cultured Sinensis supplement had less elevation of serum ALT concentration, Cordyceps Sinensis and Mycelium of Cultured Sinensis administration restored the reduction of hepatic microsomal P450 protein content as well as inducing an increase in hepatic GSH concentration. Additionally, Cordyceps Sinensis and Mycelium of Cultured Sincnsis treatment inhibited the elevation of hepatic CYP450 protein after CCl_4 intoxication. Condusion The protect effect of Cordyceps Sinensis and Mycelium of Cultured Sinensis may be due to its abilitity to increase CYP450 content which decreased in CCl_4-induced liver in combination with increasing the activities of antioxidant en-zyme.
