Early screening of pancreatic cancer by combination of EUS with tumor marker detection
10.3760/cma.j.issn.1007-8118.2010.03.004
- VernacularTitle:超声内镜联合肿瘤标记物对胰腺癌早期筛查的研究
- Author:
Shuyi ZHANG
;
Wen LI
;
Jie DU
;
Ximo WANG
;
Tan JIANG
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms;
Endoscopic ultrasonic;
Screening;
CA19-9;
CA242
- From:
Chinese Journal of Hepatobiliary Surgery
2010;16(3):170-172
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the clinical value of EUS in combination with detection of CA19-9 and CA242 for early diagnosis of pancreatic cancer.Methods General features of high-risk group were determed by EUS and the plasma levels of CA19-9 and CA242 measured by ELISA.Results The serum level of CA19-9 was abnormal in 9.80% (10/102) and that of CA242 in 12.75% (13/102) of the patients.They were both abnormal in 7 cases.Of the 7 cases, 3 were found to suffer from pancreatic cancer by EUS, 1 had the tumor that had been clinically confirmed, 1 had posterior peritoneal tumor and 2 were normal.Among 102 cases detected by EUS, 2 showed low echo in pan-creatic head, 2 semi-cyst, 3 pancreatic cancer and proved by pathology.Accurate diagnotic rate, sensi-tivity and specificity were 90.20% (92/102), 50% (4/8) and 93.62% (88/94), respectively, for serum CA19-9.For the serum CA242, the 3 parameters were 87.25% (89/102), 50% (4/8) and 90.43% (85/94), respectively.For combination of both methods, they were 98.04% (100/102), 100%(8/8) and 97.87%(92/94), respectively.Accurate diagnostic rate of the latter was significantly higher than that of the former 2(P＜0.05).Concision Combination of EUS with detection of serum CA19-9 and CA242 is of great vlaue for early screening of pancreatic cancer.
