Portal vein arterialization by right renal artery in portacaval shunt rats
10.3760/cma.j.issn.1007-631X.2010.03.017
- VernacularTitle:利用右肾动脉行入肝门静脉动脉化加门腔分流术的实验研究
- Author:
Jian LI
;
Qi LIU
;
Xiaodong GUAN
;
Yuyan XIE
;
Hongtao CHEN
;
Baimeng ZHANG
- Publication Type:Journal Article
- Keywords:
Renal artery;
Portal vein;
Portacaval shunt,surgical;
Portal pressure;
Models,animal
- From:
Chinese Journal of General Surgery
2010;25(3):227-230
- CountryChina
- Language:Chinese
-
Abstract:
Objective To estabhsh a rat portacaval shunt model of portal vein arterialization (PVA)by using right renal artery,andtoinvestigateitsinfluence on portal velnpressure,liver funciton and hepatic pathology.Method Forty-three Sprague-Dawley rats were assigned to PVA group(33 rats)and control group(10 rats).Portal pressure,liver function and pathological changes were evaluated at day 2,2 weeks and 2 months after surgery,respectively.Results The experimental model was successfully established in 30 out of 33(91%)rats.At day 2,2 weeks and 2 months after the operation,the portal pressure increased significanfly(P<0.05)compared with the control group,but no significant differences were found in the senrum level of alanine amlnotransferase,total bilirubin,total bile acid and creatinine.There were no patholgiccal changes from day 2 to 2 weeks after surgery,only postoperative expanslon of the sinusoidal snace was found on 2 months after surgery.Conclusion The rat model of PVA by renal artery was successfully established with the hand-suture mierosurgical techniques.The portal vein pressure maintained at a high level after PVA,meanwhile,no negative effect was found on the liver function and hepatic histological structure changes.
