Progress in effect of connective tissue growth factor in vascular smooth muscle cell's proliferation,migration and deposition of extracellular matrix
10.3760/cma.j.issn.1673-4408.2010.02.014
- VernacularTitle:结缔组织生长因子对血管平滑肌细胞增殖、迁移和细胞外基质沉积影响的研究进展
- Author:
Yu HU
;
Bin LIU
- Publication Type:Journal Article
- Keywords:
Connective tissue growth factor;
Vascular smooth muscle cell;
Extracellular matrix
- From:
International Journal of Pediatrics
2010;37(2):152-154
- CountryChina
- Language:Chinese
-
Abstract:
Congenital heart disease often lost the opportunity of radical sureryfor secondary pulmonary hypertension.pulmonary hypertension is pathologicallycharacterizzed by pulmonary vascular remodeling,including the vascular smooth musclecell' s proliferation,migration and extracelluar matrix deposition,Recently,someresearchers have found that connective tissue growth factor can bind with somesurface receptors of vascular smooth muscle cells,causing some biological behaviorchanges such as proliferation,migration and extracellular matrix abnormaldeposition,and activating crresponding gene expression through this signaltransduction pathway.Pulmonary vascular remodeling may be one of the molecularpathogenesis in pulmonary hypertension.
