Progress in immunopathogenesis of Henoch-Sch(o)nlein purpura
10.3760/cma.j.issn.1673-4408.2010.02.024
- VernacularTitle:过敏性紫癜免疫学发病机制研究进展
- Author:
Xiaojing HU
;
Fange LIU
- Publication Type:Journal Article
- Keywords:
Henoch-Schnlein purpura;
Immune abnormalitiy
- From:
International Journal of Pediatrics
2010;37(2):183-185
- CountryChina
- Language:Chinese
-
Abstract:
Henoch-Schnlein purpura(HSP) is a common autoimmune small vessel vasculitis that primarily affects children.Although the pathogenesis of HSP is unknown,there are tantalizing clues on the immune abnormalities mediated by IgA,which mainly affects the vessels of the skin,gastrointestinal tract and kidneys.The reasons of deposition maybe involve in the increases of serum IgA,the abnormalities of IgA-specific autoantibodies,structures and acceptors of IgA1,complements,and so on,which mediates the abnormal expressions of adhesion molecules and cytokines.
