Molecular mechanisms of angiogenesis after cerebral ischemia
10.3760/cma.j.issn.1673-4165.2010.02.014
- VernacularTitle:脑缺血后血管生成的分子机制
- Author:
Jian ZHANG
;
Jinsheng ZENG
- Publication Type:Journal Article
- Keywords:
Brain ischemia;
Neovascularization,physiologic;
Cell differentiation;
Cell movement;
Angiogenic proteins;
Endothelial cells;
Stroke
- From:
International Journal of Cerebrovascular Diseases
2010;18(2):146-150
- CountryChina
- Language:Chinese
-
Abstract:
Angiogenesis is an important self-repair and remodeling mechanism after cerebral ischemia. It plays pivotal roles in promoting local blood circulation, protecting neurons and improving neurological function after cerebral ischemia. A variety of molecules and signal transduction pathways involved in the regulation of the process, including angiogenin, growth factors, matrix metalloproteinases, tissue kallikrein and anti-angiogenic proteins. This article reviews the roles of these molecules and signal transduction pathways in angiogenesis after cerebral ischemia.
