Glial microenvironment and repair in central nervous system injury
10.3760/cma.j.issn.1673-4165.2010.02.015
- VernacularTitle:胶质微环境与中枢神经系统损伤修复
- Author:
Han ZHANG
;
Zhida SU
- Publication Type:Journal Article
- Keywords:
Brain injuries;
Spinal cord injuries;
Neuroglia;
Homeostasis;
Astrocytes;
Microglia;
Oligodendroglia;
Nerve regeneration;
Neuronal plasticity;
Neurons
- From:
International Journal of Cerebrovascular Diseases
2010;18(2):151-156
- CountryChina
- Language:Chinese
-
Abstract:
Central nervous system (CNS) injury, including brain injury and spinal cord injury, has higher disability and mortality. Therefore, CNS injury repair has been a research emphasis and focus in the field of neuroscience. The limited neurons intrinsic regenerative capacity in adult mammalians is one of the reasons of regeneration difficulties after CNS injury. However, the more important reason is the formation of inhibitive glial microenvironment at the local lesion sites. This article reviews the roles of all types of cells, such as astrocyte, microglia, taxi oligodendroglia in gtial microenvironment in CNS injury repair.
