PAX2 expression and its significance in kidneys
10.3760/cma.j.issn.1673-4408.2010.02.025
- VernacularTitle:PAX2在肾脏中表达及其意义
- Author:
Li LI
;
Dongmei ZHAO
;
Yubin WU
- Publication Type:Journal Article
- Keywords:
PAX2;
Kidney;
Kidney disease
- From:
International Journal of Pediatrics
2010;37(2):186-189
- CountryChina
- Language:Chinese
-
Abstract:
PAX2 gene encodes a nuclear transcription factor and plays a pivotal role for embryonic kidney development.It is expressed during the entire developmental process of pronephron,mesonephron and metanephron,involving in the regulation of embryonic kidney development at various fetal stages,but its expression disappeared in mature nephrons.Recently,it was found that PAX2 was re-expressed in nephropathy.Gene mutation and re-expression of PAX2 are closely related with congenital and acquired renal diseases.This paper reviews the role and significance of PAX2 expression in kidney disease from the aspects of normal expression,gene mutation and abnormal expression.
