Relationship of tumor necrosis factor gene polymorphism and acute graft-versus-host disease after unrelated ailogeneic hematopoietic stem cell transplantation
10.3760/cma.j.issn.0578-1426.2010.04.014
- VernacularTitle:无关供者异基因造血干细胞移植中急性移植物抗宿主病与肿瘤坏死因子基因多态性的关系
- Author:
Lai JIN
;
Haowen XIAO
;
Xiaoyu LAI
;
Gongqiang WU
;
Yi LUO
;
Jimin SHI
;
Yamin TAN
;
He HUANG
- Publication Type:Journal Article
- Keywords:
Hematopoietic stem cell transplantation,allogeneic;
Tumor necrosis factor;
Polymorphism,single nucleotide;
Graft-versus-host disease
- From:
Chinese Journal of Internal Medicine
2010;49(4):320-324
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between tumor necrosis factor (TNF) gene polymorphisms in donors and recipients and the incidence and severity of acute graft-versus-host diseases (aGVHD) after unrelated allogeneic hematopoietic stem cell transplantation (alIo-HSCT). Methods Single nucleotide polymorphisms (SNPs) of TNFα-238 (G/A), TNFα-857 (C/T), TNFα-863 (C/A), TNFα-1031 (T/C), TNFβ + 252 (A/G) were analyzed by Multiplex SNaPshot analysis in 76 pairs of donors and recipients. Results Transplantation involving donors with TNFα-857 CC genotype resulted in a higher incidence of grade Ⅱ-Ⅳ aGVHD than donors with CT genotype (91.3% vs 8. 7% , P =0. 039). In the 23 patients with grade Ⅱ-Ⅳ aGVHD, no patients had TNFβ +252 AA genotype, 19 (82.6%) had GA genotype and 4 (17.4%) had GG genotype. There was a significant difference in the distribution pattern of the TNFβ +252 (AA, GA and GG) genotypes in these patients (P =0.03). There was no significant association of TNFα-238 (G/A), TNFα-863 (C/A) and TNFα-1031 (T/C) polymorphisms with the risk of aGVHD. Conclusion These results suggest donor TNFα-857 CC genotype is related to a higher incidence of grade Ⅱ -Ⅳ aGVHD, and patients with TNFβ +252 AA genotype have protection against the risk of grade Ⅱ -Ⅳ aGVHD.
