Correlative study of contrast-enhanced ultrasonography and microvessel density in hepatocellular carcinoma
10.3760/cma.j.issn.1004-4477.2010.03.014
- VernacularTitle:肝细胞肝癌超声造影与微血管密度的相关性研究
- Author:
Min BAI
;
Lianfang DU
;
Xuemei ZHANG
;
Fan LI
;
Ying WU
;
Huiping ZHANG
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Microbubbles;
Carcinoma,hepatocellular;
Neovascularization,pathologic
- From:
Chinese Journal of Ultrasonography
2010;19(3):223-226
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between quantitative parameters of contrast-enhanced ultrasonography(CEUS)and microvessel density(MVD)in hepatocellular carcinoma(HCC),and to investigate the value of CEUS in noninvasively assessing HCC angiogenesis.Methods The patients with 28 HCCs confirmed by pathology were examined by CEUS.A new type quantification software SW-UCS was used to delineate time-intensity curve(TIC)and to obtain quantitative parameters of HCC and hepatic parenchyma in region of interest.The quantitative parameters were compared with MVD,which was counted by immunohistochemistry method using CD34 antibody,and the correlation between them was studied.Results The TICs of HCC showed typical contrast-enhancement pattern of"fast-in and fast-out"comparing with normal hepatic parenchyma.There were significant differences between HCC and hepatic parenchyma in slope of rise time(a3),time to initial peak(TTP),peak intensity(PI),increased signal intensity(ISI)and acceleration time(ACT)(P＜0.05).MVD in HCC(49.36±12.57)was higher than that in hepatic parenchyma(32.46±11.78,P=0.000).For HCC,the PI,ISI and area under curve were positively correlated with MVD,while the slope of decrease to half of peak(a2)was negatively correlated with MVD (P＜0.05).Conclusions The quantitative parameters of CEUS in HCC were correlated with MVD,CEUS can evaluate the angiogenesis of HCC in vivo noninvasively.
